Deloose S T P, Smit L A, Pals F T, Kersten M-J, van Noesel C J M, Pals S T
Department of Pathology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Leukemia. 2005 May;19(5):851-5. doi: 10.1038/sj.leu.2403709.
Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma. We here report a high incidence of KSHV infection in solid HIV-associated immunoblastic/plasmablastic non-Hodgkin's lymphomas (NHLs), in patients lacking effusions and without evidence of (prior) MCD. Within a cohort of 99 HIV-related NHLs, 10 cases were found to be KSHV positive on the basis of immunostaining for KSHV LNA-1 as well as KSHV-specific polymerase chain reaction. All but one of the tumors coexpressed Epstein-Barr virus. Interestingly, all KSHV-positive cases belonged to a distinctive subgroup of 26 diffuse large B-cell lymphomas characterized by the expression of CD138 (syndecan-1) and plasmablastic/immunoblastic morphology. These KSHV-positive lymphomas were preceded by Kaposi sarcoma in 60% of the patients and involved the gastrointestinal tract in 80%. Our results indicate that KSHV infection is not restricted to PEL and MCD; it is also common (38%) in HIV-related solid immunoblastic/plasmablastic lymphomas.
卡波西肉瘤相关疱疹病毒（KSHV）已知与两种不同的淋巴增殖性疾病有关：原发性渗出性淋巴瘤（PEL）和多中心Castleman病（MCD）/MCD相关浆母细胞淋巴瘤。我们在此报告，在缺乏渗出液且无（既往）MCD证据的HIV相关实体免疫母细胞/浆母细胞性非霍奇金淋巴瘤（NHL）患者中，KSHV感染的发生率很高。在99例HIV相关NHL患者队列中，基于KSHV LNA-1免疫染色以及KSHV特异性聚合酶链反应，发现10例患者KSHV呈阳性。除1例肿瘤外，所有肿瘤均共表达爱泼斯坦-巴尔病毒。有趣的是，所有KSHV阳性病例均属于26例弥漫性大B细胞淋巴瘤的一个独特亚组，其特征为CD138（syndecan-1）表达及浆母细胞/免疫母细胞形态。这些KSHV阳性淋巴瘤患者中60%之前患有卡波西肉瘤，80%累及胃肠道。我们的结果表明，KSHV感染不仅限于PEL和MCD；在HIV相关实体免疫母细胞/浆母细胞淋巴瘤中也很常见（38%）。
