Hajri A, Aprahamian M, Damgé C
INSERM Unit 61, Digestive Cell Biology and Physiopathology, Strasbourg, France.
Regul Pept. 1991 Feb 1;32(2):227-37. doi: 10.1016/0167-0115(91)90049-m.
This work investigates the effects of the long-acting somatostatin analogue, octreotide also named SMS 201-995 or Sandostatin, on pancreatic growth in function of the dose and duration of treatment. Octreotide was administered s.c. twice daily, while pancreatico-trophic peptides, caerulein and CCK-8 (1.8 nmol/kg b.wt.) or GRP (3.6 nmol/kg b.wt.) were administered s.c. three times daily. Octreotide (1,10,20 micrograms/kg b.wt.) administered for 4 days reduced pancreatic growth induced by caerulein in a dose-dependent manner. This effect, significant from 10 micrograms/kg, was more obvious with 20 micrograms/kg. At this latter dose, octreotide inhibited significantly the increase in pancreatic weight and protein, RNA, DNA and enzyme content induced by a 4- or 10-day treatment with GRP. A similar effect was observed after a 4-day treatment with CCK-8, but after a 10-day treatment only protein and enzyme contents were reduced. Octreotide by itself did not affect pancreatic size and composition after a 10-day treatment, but decreased enzyme content after a 4-day treatment. It is concluded that octreotide exerts an antitrophic effect on the rat exocrine pancreas which depends on the dose and duration of treatment and can be modulated by the trophic factor applied for a long-term.
本研究探讨长效生长抑素类似物奥曲肽（也称为SMS 201-995或善得定）对胰腺生长的影响，该影响取决于治疗剂量和持续时间。奥曲肽每日皮下注射两次，而促胰生长肽、蛙皮素和CCK-8（1.8 nmol/kg体重）或胃泌素释放肽（3.6 nmol/kg体重）则每日皮下注射三次。以1、10、20微克/千克体重的剂量给予奥曲肽4天，可剂量依赖性地减少蛙皮素诱导的胰腺生长。从10微克/千克体重起此效应显著，20微克/千克体重时更明显。在此较高剂量下，奥曲肽显著抑制了胃泌素释放肽4天或10天治疗所诱导的胰腺重量及蛋白质、RNA、DNA和酶含量的增加。用CCK-8进行4天治疗后也观察到类似效应，但10天治疗后仅蛋白质和酶含量降低。奥曲肽单独使用10天治疗后不影响胰腺大小和组成，但4天治疗后可降低酶含量。结论是，奥曲肽对大鼠胰腺外分泌部具有抗生长作用，该作用取决于治疗剂量和持续时间，并且可被长期应用的营养因子所调节。
