Morisset J
Regul Pept. 1984 Dec;10(1):11-22. doi: 10.1016/0167-0115(84)90048-x.
The increases in DNA synthesis and total DNA content after caerulein treatment support the trophic effect of this CCK analog on the pancreas. Over a 15 day caerulein treatment, pancreatic growth plateaued after 5 days and somatostatin is believed to be responsible for this phenomenon. The present study was undertaken to test this possibility. Rats were treated for 2 or 4 days with caerulein (1 microgram X kg-1), somatostatin antiserum plus caerulein or caerulein plus somatostatin (600 micrograms X kg-1). Caerulein increased all parameters studied after 2 and 4 days; pancreatic hyperplasia was established after 2 days. The somatostatin antiserum significantly enhanced the effect of caerulein, especially on DNA synthesis and contents after 2 and 4 days. The trophic effect of caerulein was significantly reduced by somatostatin dramatically so with respect to hyperplasia. The effects of the somatostatin antiserum and those of somatostatin on stimulated pancreatic growth support the hypothesis that somatostatin may be considered an endogenous growth inhibitory factor for the pancreas.
蛙皮素处理后DNA合成及总DNA含量的增加支持了这种CCK类似物对胰腺的营养作用。在15天的蛙皮素处理过程中，胰腺生长在5天后趋于平稳，而生长抑素被认为是造成这一现象的原因。本研究旨在验证这一可能性。用蛙皮素（1微克/千克）、生长抑素抗血清加蛙皮素或蛙皮素加生长抑素（600微克/千克）对大鼠进行2天或4天的处理。蛙皮素在2天和4天后增加了所有研究参数；2天后出现胰腺增生。生长抑素抗血清显著增强了蛙皮素的作用，尤其是在2天和4天后对DNA合成及含量的影响。生长抑素显著降低了蛙皮素的营养作用，在增生方面更是如此。生长抑素抗血清和生长抑素对胰腺生长刺激的作用支持了这样一种假说，即生长抑素可被视为胰腺的内源性生长抑制因子。
