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本文引用的文献

1
Simultaneous measurements of free amino acid patterns of plasma, muscle and erythrocytes in healthy human subjects.对健康人体受试者的血浆、肌肉和红细胞中的游离氨基酸模式进行同步测量。
Clin Nutr. 1997 Dec;16(6):299-305. doi: 10.1016/s0261-5614(97)80015-5.
2
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.免疫抑制剂雷帕霉素模拟了一种不同于氨基酸和葡萄糖剥夺的饥饿样信号。
Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/MCB.22.15.5575-5584.2002.
3
Does enteral glutamine modulate whole-body leucine kinetics in hypercatabolic dogs in a fed state?在进食状态下，肠内谷氨酰胺是否会调节分解代谢亢进犬的全身亮氨酸动力学？
Metabolism. 2002 May;51(5):628-35. doi: 10.1053/meta.2002.32018.
4
Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study.静脉补充谷氨酰胺对极低出生体重儿蛋白质代谢的急性影响：一项稳定同位素研究。
Pediatr Res. 2002 Jan;51(1):87-93. doi: 10.1203/00006450-200201000-00016.
5
Effects of glutamine deprivation on protein synthesis in a model of human enterocytes in culture.谷氨酰胺缺乏对体外培养的人肠上皮细胞模型中蛋白质合成的影响。
Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1340-7. doi: 10.1152/ajpgi.2001.281.6.G1340.
6
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production.测定肌肉蛋白中的谷氨酰胺有助于准确评估蛋白水解作用以及从头合成产生的内源性谷氨酰胺生成情况。
Am J Clin Nutr. 1999 Oct;70(4):484-9. doi: 10.1093/ajcn/70.4.484.
7
Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism.苯丁酸盐诱导的人体谷氨酰胺耗竭：对亮氨酸代谢的影响。
Am J Physiol. 1998 May;274(5):E801-7. doi: 10.1152/ajpendo.1998.274.5.E801.
8
Oral glutamine slows down whole body protein breakdown in Duchenne muscular dystrophy.口服谷氨酰胺可减缓杜氏肌营养不良症患者全身蛋白质分解。
Pediatr Res. 1998 Feb;43(2):222-6. doi: 10.1203/00006450-199802000-00011.
9
Effect of glutamine on leucine metabolism in humans.谷氨酰胺对人体亮氨酸代谢的影响。
Am J Physiol. 1996 Oct;271(4 Pt 1):E748-54. doi: 10.1152/ajpendo.1996.271.4.E748.
10
Leucine metabolism at graded amino acid intakes in children receiving parenteral nutrition.接受肠外营养的儿童在不同氨基酸摄入量时的亮氨酸代谢
Am J Physiol. 1993 Oct;265(4 Pt 1):E540-6. doi: 10.1152/ajpendo.1993.265.4.E540.

血浆谷氨酰胺的急性消耗会增加泼尼松治疗的人体内亮氨酸的氧化。

Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans.

作者信息

Le Bacquer Olivier, Mauras Nelly, Welch Susan, Haymond Morey, Darmaun Dominique

机构信息

INSERM U.539, Centre de Recherche en Nutrition Humaine, Nantes, France.

出版信息

Clin Nutr. 2007 Apr;26(2):231-8. doi: 10.1016/j.clnu.2006.09.010. Epub 2006 Nov 13.

DOI:10.1016/j.clnu.2006.09.010
PMID:17097772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1949027/
Abstract

BACKGROUND, AIMS & METHODS: To determine whether depletion in plasma glutamine worsens the catabolic response to corticosteroids, seven healthy volunteers received oral prednisone for 6 days on two separate occasions, at least 2 weeks apart, and in random order. On the sixth day of each treatment course, they received 5 h intravenous infusions of L-[1-(14)C]-leucine and L-[1-(13)C]-glutamine in the postabsorptive state (1) under baseline conditions (prednisone only day) and (2) after 24h of treatment with phenylbutyrate (prednisone+phenylbutyrate day), a glutamine chelating agent.

RESULTS

Phenylbutyrate treatment was associated with (1) an approximately 15% decline in plasma glutamine concentration (627+/-39 vs. 530+/-31 micromol l(-1); P<0.05), (2) no change in leucine appearance rate, an index of protein breakdown (124+/-9 vs. 128+/-9 micromol kg(-1) h(-1); NS) nor in non-oxidative leucine disposal, an index of whole body protein synthesis (94+/-9 vs. 91+/-7 micromol kg(-1) h(-1); NS), and (3) a approximately 25% rise in leucine oxidation (30+/-1 vs. 38+/-2 micromol kg(-1) h(-1), P<0.05), despite an approximately 25% decline (P<0.05) in leucine concentration.

CONCLUSIONS

In a model of mild, stress-induced protein catabolism, depletion of plasma glutamine per se may worsen branched chain amino acid and protein wasting.

摘要

背景、目的与方法：为了确定血浆谷氨酰胺水平降低是否会加重对皮质类固醇的分解代谢反应，7名健康志愿者分两次、至少间隔2周且随机顺序口服泼尼松6天。在每个治疗疗程的第6天，他们在（1）基线条件下（仅泼尼松日）和（2）用苯丁酸钠治疗24小时后（泼尼松+苯丁酸钠日），处于吸收后状态接受5小时静脉输注L-[1-(14)C]-亮氨酸和L-[1-(13)C]-谷氨酰胺，苯丁酸钠是一种谷氨酰胺螯合剂。

结果

苯丁酸钠治疗与以下情况相关：（1）血浆谷氨酰胺浓度下降约15%（627±39对530±31微摩尔/升；P<0.05），（2）亮氨酸出现率无变化，亮氨酸出现率是蛋白质分解的指标（124±9对128±9微摩尔/千克(-1)小时(-1)；无显著性差异），全身蛋白质合成指标非氧化亮氨酸处置也无变化（94±9对91±7微摩尔/千克(-1)小时(-1)；无显著性差异），以及（3）亮氨酸氧化增加约25%（30±1对38±2微摩尔/千克(-1)小时(-1)，P<0.05），尽管亮氨酸浓度下降约25%（P<0.05）。

结论

在轻度应激诱导的蛋白质分解代谢模型中，血浆谷氨酰胺本身的消耗可能会加重支链氨基酸和蛋白质的消耗。