de Oliveira e Silva A, Roldan-Molina F, dos Santos T E, Santo G C, Miranda M P, Genzini T, Neves L B, D'Albuquerque L A
Serviço de Fígado do Hospital da Beneficência Portuguesa de São Paulo.
Arq Gastroenterol. 1990 Apr-Jun;27(2):83-94.
Serum levels of alkaline phosphatase, gamma-glutamyltranspeptidase, -1 fucosidase and glutathione-S-transferase are increased in 60, 90, 75 and 64% of patients with hepatocellular carcinoma. In these patients the mean plasma fibrinogen levels is 461.78 mg/dl, while mean serum copper is 200.50 mg/dl. Serum levels of desgamma-carboxiprothrombin is over 900 mg/dl in 67% of the patients (60% of them have HB virus, mostly anti HBe positive). Forty to 95% of them have increased levels of -fetoprotein (AFP). The authors suggest that cirrhotic patients, with or without HB virus, specially those with increased AFP, should have ultrasound examination of the liver every 6 months. This method of imaging has been shown to be more sensitive than AFP (72% versus 25%) in the detection of hepatocellular carcinoma smaller than 2 cm in diameter.
在60%、90%、75%和64%的肝细胞癌患者中，血清碱性磷酸酶、γ-谷氨酰转肽酶、α-1岩藻糖苷酶和谷胱甘肽-S-转移酶水平升高。这些患者的平均血浆纤维蛋白原水平为461.78mg/dl，而平均血清铜为200.50mg/dl。67%的患者血清去γ-羧基凝血酶原水平超过900mg/dl（其中60%感染乙肝病毒，大多抗-HBe阳性）。40%至95%的患者甲胎蛋白（AFP）水平升高。作者建议，无论有无乙肝病毒感染的肝硬化患者，尤其是AFP升高者，应每6个月进行一次肝脏超声检查。在检测直径小于2cm的肝细胞癌方面，这种成像方法已被证明比AFP更敏感（72%对25%）。
