Mangino Massimo, Braund Peter, Singh Ravi, Steeds Rick, Thompson John R, Channer Kevin, Samani Nilesh J
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Atherosclerosis. 2007 Sep;194(1):112-5. doi: 10.1016/j.atherosclerosis.2006.10.004. Epub 2006 Nov 13.
Myocardial infarction (MI) is currently among the leading causes of death in the developed world. A functional SNP (rs7291467) in galectin-2 (LGALS2), a protein involved in the LTA cascade, has been associated with susceptibility to MI in the Japanese population. We explored for the first time the hypothesis that the same SNP could be associated with the risk of MI in the British population. We conducted a case-control association study on a cohort of 752 British MI patients and 705 population controls. Power calculations showed that our resource had 98% of power to detect a significant association at OR of 1.57, and 80% power to detect an association with an OR of 1.35 (recessive model). Despite this, we found no significant association of allele frequency with risk of MI. Stratification for age, gender and other cardiovascular risk factors also failed to reveal an association of this polymorphism with MI.
心肌梗死（MI）目前是发达国家主要的死亡原因之一。半乳糖凝集素-2（LGALS2）是一种参与LTA级联反应的蛋白质，其功能性单核苷酸多态性（SNP，rs7291467）与日本人群患心肌梗死的易感性有关。我们首次探讨了同一个SNP可能与英国人群患心肌梗死风险相关的假说。我们对752名英国心肌梗死患者和705名人群对照进行了病例对照关联研究。功效计算表明，我们的样本量有98%的把握度检测到比值比（OR）为1.57时的显著关联，有80%的把握度检测到OR为1.35（隐性模型）时的关联。尽管如此，我们未发现等位基因频率与心肌梗死风险有显著关联。按年龄、性别和其他心血管危险因素分层也未能揭示该多态性与心肌梗死的关联。
