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一名长期接受透析治疗的患者,出现髌骨及对侧股四头肌肌腱自发性断裂,与继发性甲状旁腺功能亢进相关。

Spontaneous rupture of the patellar and contralateral quadriceps tendons associated with secondary hyperparathyroidism in a patient receiving long-term dialysis.

作者信息

Chen Chiu-Ming, Chu Pauling, Huang Guo-Shu, Wang Shyu-Jye, Wu Shing-Sheng

机构信息

Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

出版信息

J Formos Med Assoc. 2006 Nov;105(11):941-5. doi: 10.1016/S0929-6646(09)60180-7.

Abstract

Although spontaneous rupture of the extensor tendon of the knee is more likely to occur in uremic patients with secondary hyperparathyroidism, simultaneous ruptures of bilateral knee extensor tendons is a rarely reported condition. We describe a 30-year-old man with uremia who underwent subtotal parathyroidectomy because of secondary hyperparathyroidism with very high serum parathyroid hormone (PTH) level (1940.4 pg/mL). Two weeks later, he complained of a sharp pain in both knees without trauma when he walked downstairs with his left knee forward and right knee behind. Spontaneous simultaneous ruptures of the right patellar tendon and the left quadriceps tendon were diagnosed and surgically repaired. The mechanism of spontaneous tendon rupture in uremic patients with secondary hyperparathyroidism seems to be related to high PTH level which results in osteolytic bone resorption at the tendon insertion site. Early surgical repair, control of secondary hyperparathyroidism, early use of vitamin D analogs, and total parathyroidectomy with or without autotransplantation of part of the parathyroid gland, can treat and prevent tendon rupture or re-rupture with satisfactory results.

摘要

虽然膝关节伸肌腱自发性断裂更易发生于患有继发性甲状旁腺功能亢进的尿毒症患者,但双侧膝关节伸肌腱同时断裂是一种鲜有报道的情况。我们描述了一名30岁的尿毒症男性患者,因其继发性甲状旁腺功能亢进且血清甲状旁腺激素(PTH)水平极高(1940.4 pg/mL)而接受了甲状旁腺次全切除术。两周后,当他左腿在前、右腿在后下楼时,在无外伤的情况下双侧膝关节出现剧痛。诊断为右髌腱和左股四头肌肌腱同时自发性断裂,并进行了手术修复。患有继发性甲状旁腺功能亢进的尿毒症患者肌腱自发性断裂的机制似乎与高水平的PTH有关,这会导致肌腱附着部位的溶骨性骨吸收。早期手术修复、控制继发性甲状旁腺功能亢进、早期使用维生素D类似物以及甲状旁腺全切除术(伴或不伴部分甲状旁腺自体移植),可以治疗并预防肌腱断裂或再断裂,效果令人满意。

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