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人正常B淋巴细胞在用商陆有丝分裂原刺激后，在扩散盒培养中可产生对粒细胞祖细胞的促生长活性。

Human normal B lymphocytes produce a growth-promoting activity for granulocyte progenitors in diffusion chamber culture after stimulation with pokeweed mitogen.

作者信息

Hansz J, Kozłowska-Skrzypczak M

机构信息

Department of Haematology, Academy of Medicine, Poznán, Poland.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(5):677-84.

PMID:1709901
Abstract

We have measured the effect of normal B lymphocytes on more primitive granulocyte progenitors (CFU-dG) clonal growth in double-diffusion chamber culture in vivo. It was found that pokeweed mitogen (PWM) stimulated B cells produce a growth-promoting activity which augments the CFU-dG--derived myeloid colony formation in a dose-dependent fashion. All colonies formed under the experimental conditions were composed exclusively of granulocytes at different stages of maturation. Unstimulated B lymphocytes did not effect the CFU-dG clonal proliferation.

摘要

我们已经在体内双扩散小室培养中测量了正常B淋巴细胞对更原始的粒细胞祖细胞（CFU-dG）克隆生长的影响。发现商陆丝裂原（PWM）刺激的B细胞产生一种促生长活性，该活性以剂量依赖的方式增强CFU-dG衍生的髓系集落形成。在实验条件下形成的所有集落均仅由处于不同成熟阶段的粒细胞组成。未受刺激的B淋巴细胞不影响CFU-dG克隆增殖。

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