Emir S, Büyükpamukçu M, Köseoğlu V, Hasçelik G, Akyüz C, Kutluk T, Varan A
Department of Pediatric Oncology, SB Ankara Dişkapi Children's Training and Research Hospital, Ankara, Turkey.
Postgrad Med J. 2006 Nov;82(973):760-2. doi: 10.1136/pmj.2005.041293.
Varicella infection can be a severe disease, especially in immunosuppressed patients. Here, experience with live varicella vaccine to prevent varicella infection is reported in children who were undergoing treatment for lymphoma and solid tumours.
40 children, aged between 12 months and 15 years with no clinical history of varicella, were vaccinated with live varicella vaccine. All received two doses of the vaccine subcutaneously 4 weeks apart. Serum samples were taken before the first dose and 6 weeks after the second dose of vaccine.
Before vaccination, 32 patients were seronegative for varicella and eight were seropositive. Seroconversion was observed 6 weeks after the second dose in 24 of the 32 (75%) seronegative children. In 4 of 8 previously seropositive patients, antibody titres increased after immunisation. Zoster infection occurred 5 weeks after the second dose of vaccine in only one previously seronegative child. 7 children, who had responded to the vaccine, have been exposed to varicella in their families or in school without contracting clinical disease.
Although the small number of patients in our group prevents us from drawing definitive conclusions, the varicella vaccine seems to be well tolerated and can be administered to children with lymphoma and solid tumours undergoing treatment.
水痘感染可能是一种严重疾病，尤其是在免疫抑制患者中。本文报告了在接受淋巴瘤和实体瘤治疗的儿童中使用水痘活疫苗预防水痘感染的经验。
40名年龄在12个月至15岁之间且无水痘临床病史的儿童接种了水痘活疫苗。所有儿童均皮下注射两剂疫苗，间隔4周。在第一剂疫苗接种前和第二剂疫苗接种后6周采集血清样本。
接种疫苗前，32例患者水痘血清学检测为阴性，8例为阳性。32例血清学阴性儿童中有24例（75%）在第二剂疫苗接种后6周出现血清转化。8例先前血清学阳性患者中有4例在免疫后抗体滴度升高。仅1例先前血清学阴性儿童在第二剂疫苗接种后5周发生带状疱疹感染。7例对疫苗有反应的儿童在家庭或学校接触水痘后未患临床疾病。
尽管我们研究组的患者数量较少，无法得出明确结论，但水痘疫苗似乎耐受性良好，可用于正在接受治疗的淋巴瘤和实体瘤儿童。
