Ninane J, Latinne D, Heremans-Bracke M T, De Bruyere M, Cornu G
Postgrad Med J. 1985;61 Suppl 4:97-102.
One dose containing 3,100 PFU of a live attenuated Oka-strain varicella vaccine (Varilrix, Smith Kline-RIT, Belgium) was administered subcutaneously to 45 children, 26 of whom were suffering from acute leukaemia and 19 from solid malignant tumours. Their immunological status had been severely compromised by chemotherapy as evidenced by markedly low values for all immunological parameters. Of the 31 children seronegative for varicella at the time of vaccination, 70%, 85%, 75%, and 40% had varicella serum antibodies at 1, 2, 3, and 12 months after vaccination, respectively. Evaluation of the immunological parameters indicated that they were of no predictive value regarding the antibody response of the patients to the vaccine. Eight children (18%) developed varicella after vaccination. In one case, the disease was caused by the vaccine virus while in another, the vaccine virus was probably also responsible. The remaining six cases were caused by wild virus. The antibody response and accompanying protection against disease induced by the vaccine in severely immunodepressed patients is acceptable, but clearly lower and of shorter duration than in normal subjects. Thus, in immunocompromised patients, booster doses of the vaccine may be required at relatively short intervals.
将含有3100个蚀斑形成单位（PFU）的减毒活Oka株水痘疫苗（Varilrix，比利时史克 - RIT公司）皮下注射给45名儿童，其中26名患有急性白血病，19名患有实体恶性肿瘤。化疗已严重损害了他们的免疫状态，所有免疫参数值均明显偏低即证明了这一点。在接种疫苗时31名水痘血清学阴性的儿童中，分别有70%、85%、75%和40%在接种后1个月、2个月、3个月和12个月时产生了水痘血清抗体。免疫参数评估表明，它们对患者对疫苗的抗体反应没有预测价值。8名儿童（18%）在接种疫苗后患上了水痘。其中1例疾病由疫苗病毒引起，另1例疫苗病毒可能也是病因。其余6例由野生病毒引起。疫苗在严重免疫抑制患者中诱导的抗体反应及随之而来的对疾病的保护作用是可以接受的，但明显低于正常受试者且持续时间更短。因此，对于免疫受损患者，可能需要相对较短间隔时间就接种加强剂量的疫苗。
