禽成髓细胞瘤病毒核心成分对病毒蛋白的合成
Synthesis of viral proteins by the avian myeloblastosis viral core component.
作者信息
Mendelson I S
出版信息
Biochim Biophys Acta. 1975 Nov 4;407(4):442-8. doi: 10.1016/0005-2787(75)90297-x.
PMID:170991
Abstract
Avian Myeloblastosis Viral (AMV) core component was isolated and shown to synthesize AMV proteins in vitro. This reaction was linearly dependent on viral core concentration, proceeded linearly with time, and was inhibited by puromycin and aurintricarboxylic acid. The proteins synthesized in vitro co-electrophoresed and co-chromatographed with known proteins, and were immunoprecipitated by total and monospecific antibodies to known AMV proteins.
摘要
禽成髓细胞瘤病毒（AMV）核心成分被分离出来，并显示在体外能合成AMV蛋白。该反应与病毒核心浓度呈线性相关，随时间呈线性进行，并受到嘌呤霉素和金精三羧酸的抑制。体外合成的蛋白质与已知蛋白质共电泳和共色谱，并用针对已知AMV蛋白质的全抗体和单特异性抗体进行免疫沉淀。
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