Stewart R J E, Hill F W G, Masztalerz A, Jacobs J J L, Koten J W, Den Otter W
Faculty of Veterinary Science, University of Zimbabwe, PO Box MP167, Mount Pleasant, Harare, Zimbabwe.
Vet Rec. 2006 Nov 11;159(20):668-72. doi: 10.1136/vr.159.20.668.
In total, 174 bovine ocular squamous cell carcinomas of varying sizes (20 to 2800 mm(2) in area) were treated daily with peritumoural injections of solvent, or solvent containing 5000 U, 20,000 U, 200,000 U, 500,000 U, 1 million U or 2 million U interleukin-2 (IL-2) for 10 days. The tumours were measured and clinically staged before treatment and at one, three, four, nine and 20 months after treatment. After 20 months, 14 per cent of the tumours treated with the solvent had regressed completely, a significantly smaller proportion than the 55 per cent treated with 5000 U IL-2, 52 per cent treated with 20,000 U IL-2, 58 per cent treated with 200,000 U IL-2, 50 per cent treated with 500,000 U IL-2, 69 per cent of tumours treated with 1 million U IL-2, 52 per cent treated with 2 million U IL-2. The tumours on the third eyelid and limbus were the most responsive.
总共174个大小各异（面积为20至2800平方毫米）的牛眼鳞状细胞癌，每天在肿瘤周围注射溶剂，或注射含5000单位、20000单位、200000单位、500000单位、1000000单位或2000000单位白细胞介素-2（IL-2）的溶剂，持续10天。在治疗前以及治疗后1个月、3个月、4个月、9个月和20个月对肿瘤进行测量并进行临床分期。20个月后，用溶剂治疗的肿瘤中有14%完全消退，这一比例明显低于用5000单位IL-2治疗的55%、用20000单位IL-2治疗的52%、用200000单位IL-2治疗的58%、用500000单位IL-2治疗的50%、用1000000单位IL-2治疗的69%以及用2000000单位IL-2治疗的52%。第三眼睑和角膜缘的肿瘤反应最为明显。
