唐氏综合征患儿的磁场与急性白血病
Magnetic fields and acute leukemia in children with Down syndrome.
作者信息
Mejia-Arangure Juan Manuel, Fajardo-Gutierrez Arturo, Perez-Saldivar Maria Luisa, Gorodezky Clara, Martinez-Avalos Armando, Romero-Guzman Lina, Campo-Martinez Maria Angeles, Flores-Lujano Janet, Salamanca-Gomez Fabio, Velasquez-Perez Leora
机构信息
Epidemiología, Clínica, Hospital de Pediatría, Centro Médico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social, México.
出版信息
Epidemiology. 2007 Jan;18(1):158-61. doi: 10.1097/01.ede.0000248186.31452.be.
BACKGROUND
: We analyzed effects of exposure to magnetic fields on the expression of acute leukemia in children with Down syndrome (who have a 20-fold higher risk of leukemia).
METHODS
: We performed a case-control study that included 42 children with both acute leukemia and Down syndrome as cases and 124 healthy children with Down syndrome as controls. We obtained demographic information concerning the children and took spot measurements of magnetic fields at each residence.
RESULTS
: The odds ratio for direct measurements of magnetic fields >/=6.00 mG was 3.7 (95% confidence interval = 1.05-13.1).
CONCLUSION
: The association between magnetic fields and leukemia in children with Down syndrome suggests the possibility of a causal role for magnetic fields in the etiology of leukemia among a genetically susceptible subgroup of children.
背景
我们分析了暴露于磁场对唐氏综合征儿童（患白血病风险高出20倍）急性白血病表达的影响。
方法
我们进行了一项病例对照研究，其中包括42名患有急性白血病和唐氏综合征的儿童作为病例，以及124名健康的唐氏综合征儿童作为对照。我们获取了有关儿童的人口统计学信息，并在每个住所进行了磁场现场测量。
结果
直接测量磁场≥6.00毫高斯时的优势比为3.7（95%置信区间=1.05 - 13.1）。
结论
唐氏综合征儿童中磁场与白血病之间的关联表明，在基因易感性儿童亚组中，磁场在白血病病因学中可能起到因果作用。
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