Chen Jiu-Chiuan, Stone Peter H, Verrier Richard L, Nearing Bruce D, MacCallum Gail, Kim Jee-Young, Herrick Robert F, You Jinhong, Zhou Haibo, Christiani David C
Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
J Occup Environ Med. 2006 Nov;48(11):1133-42. doi: 10.1097/01.jom.0000245675.85924.7e.
We investigated whether PM2.5-mediated autonomic modulation depends on individual coronary risk profiles.
Five-minute average heart rate (HR) and heart rate variability (HRV, including standard deviation of normal-to-normal intervals [SDNN], square root of the mean squared differences of successive NN intervals [rMSSD], high frequency [HF]) were measured from 24-hour ambulatory electrocardiograms, and personal PM(2.5) exposures were monitored in a prospective study of 10 male boilermakers (aged 34.3 +/- 8.1 years). We used the Framingham score to classify individuals into low (score = 1-3) and high (score = 5-6) risk categories. Mixed-effect models were used for statistical analyses.
Each 1-mg/m(3) increase in the preceding 4-hour moving average PM(2.5) was associated with HR increase (5.3 beats/min) and HRV reduction (11.7%, confidence interval [CI] = 6.2-17.1% for SDNN; 11.1%, CI = 3.1-19.1% for rMSSD; 16.6%, CI = 1.5-31.7% for HF). Greater responses (2- to 4-fold differences) were observed in high-risk subjects than in low-risk subjects.
Our study suggests that adverse autonomic responses to metal particulate are aggravated in workers with higher coronary risk profiles.
我们研究了细颗粒物（PM2.5）介导的自主神经调节是否取决于个体的冠状动脉风险状况。
在一项对10名男性锅炉制造工人（年龄34.3±8.1岁）的前瞻性研究中，通过24小时动态心电图测量5分钟平均心率（HR）和心率变异性（HRV，包括正常到正常间期的标准差[SDNN]、连续NN间期均方差的平方根[rMSSD]、高频[HF]），并监测个人PM2.5暴露情况。我们使用弗雷明汉评分将个体分为低风险（评分=1-3）和高风险（评分=5-6）类别。采用混合效应模型进行统计分析。
前4小时移动平均PM2.5每增加1mg/m³与心率增加（5.3次/分钟）和心率变异性降低相关（SDNN降低11.7%，置信区间[CI]=6.2-17.1%；rMSSD降低11.1%，CI=3.1-19.1%；HF降低16.6%，CI=1.5-31.7%）。高风险受试者的反应比低风险受试者更大（差异为2至4倍）。
我们的研究表明，冠状动脉风险较高的工人对金属颗粒物的不良自主神经反应会加剧。
