Bateson A N, Harvey R J, Wisden W, Glencorse T A, Hicks A A, Hunt S P, Barnard E A, Darlison M G
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
Brain Res Mol Brain Res. 1991 Mar;9(4):333-9. doi: 10.1016/0169-328x(91)90081-8.
We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor alpha 1 subunit, which is extremely homologous to mammalian alpha 1 subunits. The distribution of alpha 1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha 1 subunit may not necessarily be restricted to receptors having BZI pharmacology.
