Morton C R, Hutchison W D
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra.
Neurosci Lett. 1990 Sep 18;117(3):319-24. doi: 10.1016/0304-3940(90)90684-2.
In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaining for CGRP was subsequently observed. Intravenous administration of morphine did not affect release of irCGRP detected during either non-nociceptive or nociceptive afferent stimulation. The results suggest that the analgesic action of morphine does not involve reduced release of CGRP from the central terminals of nociceptive primary afferents.
在麻醉猫中，使用抗体微探针测量在非伤害性或伤害性初级传入纤维刺激期间腰段背角中免疫反应性降钙素基因相关肽（irCGRP）的释放。在脊髓背角胶状质中检测到irCGRP的释放，随后在该处观察到CGRP的免疫染色。静脉注射吗啡不影响在非伤害性或伤害性传入刺激期间检测到的irCGRP的释放。结果表明，吗啡的镇痛作用不涉及伤害性初级传入纤维中枢终末释放CGRP的减少。
