镇痛剂量的吗啡不会降低脊髓麻醉猫背角中伤害性刺激诱发的免疫反应性神经激肽的释放。
Analgesic doses of morphine do not reduce noxious stimulus-evoked release of immunoreactive neurokinins in the dorsal horn of the spinal cat.
作者信息
Lang C W, Duggan A W, Hope P J
机构信息
Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall.
出版信息
Br J Pharmacol. 1991 Aug;103(4):1871-6. doi: 10.1111/j.1476-5381.1991.tb12344.x.
Abstract
- Antibody microprobes were used to detect immunoreactive neurokinin A release in the dorsal spinal cord of barbiturate-anaesthetized spinal cats. 2. Noxious mechanical stimulation of the ipsilateral hind paw and electrical stimulation (suprathreshold for unmyelinated primary afferent fibres) of the ipsilateral tibial nerve evoked immunoreactive neurokinin A release. 3. Systemic morphine, 5 mg kg-1, i.v., did not block immunoreactive neurokinin A release in response to these stimuli. 4. Subsequent naloxone administration, 0.5 mg kg-1, i.v., did not alter this stimulus-evoked release. 5. Basal levels of immunoreactive neurokinin A were unaltered by morphine or naloxone. 6. These results suggest that the analgesic effects of morphine at the spinal cord level are not brought about by activation of presynaptic opiate receptors on neurokinin A containing afferent terminals.
摘要
- 抗体微探针用于检测巴比妥麻醉的脊髓猫背侧脊髓中免疫反应性神经激肽A的释放。2. 对同侧后爪进行有害机械刺激以及对同侧胫神经进行电刺激（对无髓初级传入纤维为阈上刺激）可诱发免疫反应性神经激肽A的释放。3. 静脉注射5 mg/kg的全身性吗啡不会阻断这些刺激所引起的免疫反应性神经激肽A的释放。4. 随后静脉注射0.5 mg/kg的纳洛酮不会改变这种刺激诱发的释放。5. 吗啡或纳洛酮不会改变免疫反应性神经激肽A的基础水平。6. 这些结果表明，吗啡在脊髓水平的镇痛作用不是通过激活含神经激肽A的传入终末上的突触前阿片受体而产生的。
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本文引用的文献
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Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat.吗啡与脊髓神经元的脊髓上抑制：吗啡降低麻醉猫紧张性下行抑制的证据
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Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents.有证据表明，脊髓背角胶状质中的阿片受体参与了静脉注射吗啡对无髓初级传入纤维冲动脊髓传导的抑制作用。
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