Wathen N C, Cass P L, Kitau M J, Chard T
Combined Academic Department of Obstetrics, Gynaecology, St Bartholomew's Hospital, London, U.K.
Prenat Diagn. 1991 Mar;11(3):145-51. doi: 10.1002/pd.1970110303.
Separately identified samples of amniotic fluid and extraembryonic coelomic fluid obtained by high resolution transvaginal ultrasound-guided amniocentesis from 32 women between 7 and 12 weeks of pregnancy were analysed for human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). There was a highly significant difference between the hCG levels in amniotic fluid (median level 6.3 U/ml; range 1.6-310.0 U/ml) and those in extraembryonic coelomic fluid (median level 400.0 U/ml; range 135.0-2250.0 U/ml) (p less than 0.001; Mann-Whitney U-test). The levels of AFP were very similar in amniotic fluid (median 26.0 kU/ml; range 10.0-116.5 kU/ml) and extraembryonic coelomic fluid (median level 24.1 kU/ml; range 12.4-94.4 kU/ml).
通过高分辨率经阴道超声引导羊膜穿刺术，从32名怀孕7至12周的女性中分别采集羊水和胚外体腔液样本，对其进行人绒毛膜促性腺激素（hCG）和甲胎蛋白（AFP）分析。羊水hCG水平（中位数为6.3 U/ml；范围为1.6 - 310.0 U/ml）与胚外体腔液hCG水平（中位数为400.0 U/ml；范围为135.0 - 2250.0 U/ml）之间存在极显著差异（p < 0.001；曼-惠特尼U检验）。羊水（中位数为26.0 kU/ml；范围为10.0 - 116.5 kU/ml）和胚外体腔液（中位数为24.1 kU/ml；范围为12.4 - 94.4 kU/ml）中的AFP水平非常相似。
