Mori N, Oka K, Ishido T, Nakamura K
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Arch Pathol Lab Med. 1991 Jun;115(6):603-6.
We report two cases of primary gastric mantle zone lymphoma. Histologic examination revealed numerous lymphoid vague nodules in the mucosa and submucosa of the resected stomach. The neoplastic cells in these nodules were slightly larger than small lymphocytes and had more or less cleaved nuclei. Immunostaining on paraffin-embedded sections showed that the neoplastic cells in the nodules of these cases were LN-1- and LN-2+ and had monotypic immunoglobulin (IgM-lambda and IgM-kappa, respectively). Immunostaining on frozen tissue specimens showed that the neoplastic cells or nodules were positive for surface IgM, surface IgD, alkaline phosphatase, and DRC-1. One third to two thirds of the cells were Leu-1+ (CD5+). These results indicated that these cases were primary gastric mantle zone lymphoma. More attention should be paid to primary gastric mantle zone lymphoma because this disease might be erroneously diagnosed as either pseudolymphoma or reactive lymphoid hyperplasia of the stomach.
我们报告两例原发性胃套细胞淋巴瘤。组织学检查显示，在切除胃的黏膜和黏膜下层有大量模糊的淋巴样结节。这些结节中的肿瘤细胞比小淋巴细胞略大，核或多或少有裂沟。石蜡包埋切片的免疫染色显示，这些病例结节中的肿瘤细胞为LN-1-和LN-2+，且具有单型免疫球蛋白（分别为IgM-λ和IgM-κ）。冷冻组织标本的免疫染色显示，肿瘤细胞或结节对表面IgM、表面IgD、碱性磷酸酶和DRC-1呈阳性。三分之一至三分之二的细胞为Leu-1+（CD5+）。这些结果表明这些病例为原发性胃套细胞淋巴瘤。应更加关注原发性胃套细胞淋巴瘤，因为这种疾病可能会被误诊为胃假淋巴瘤或反应性淋巴组织增生。
