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Primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype.

作者信息

Ueda G, Oka K, Matsumoto T, Yatabe Y, Yamanaka K, Suyama M, Ariyama J, Futagawa S, Mori N

机构信息

Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Virchows Arch. 1996 Jul;428(4-5):311-4. doi: 10.1007/BF00196707.

DOI:10.1007/BF00196707
PMID:8764943
Abstract

We report a rare case of primary hepatic lymphoma, Stage II disease, in a 48-year-old male who had a solitary hepatic tumour measuring 4 x 4.5 x 3 cm. The tumour showed a nodular growth pattern and lymphoepithelial lesions with bile ducts. Some neoplastic nodules had a non-neoplastic atrophic germinal centre and/or a thin mantle cell layer. Morphologically, the neoplastic cells were centrocyte-like cells or intermediate lymphocytes. They expressed L26(CD20)+/LN-1(CDw75)+/-/LN-2(CD74)+/cyclin D1- and had a monotypic immunoglobulin of cytoplasmic IgM (kappa) on paraffin sections. The neoplastic cells or neoplastic nodules expressed surface IgM+/surface IgD+/-/Leu-1(CD5)+/DRC-1+/alkaline phosphatase+/B1(CD20)+/B4(CD19)- on fresh frozen sections. We therefore diagnosed this case as primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. We confirm that it is difficult to differentiate extranodal marginal zone B-cell lymphoma (low grade B-cell lymphoma of mucosa-associated lymphoid tissue type; MALT lymphoma) and mantle cell lymphoma.

摘要

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本文引用的文献

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Immunohistochemical characteristics of monocytoid B cell lymphoma, mantle zone lymphoma, small lymphocytic lymphoma (or B chronic lymphocytic leukemia), and hairy cell leukemia.单核细胞样B细胞淋巴瘤、套细胞淋巴瘤、小淋巴细胞淋巴瘤（或B细胞慢性淋巴细胞白血病）及毛细胞白血病的免疫组化特征
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Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma.原发性肝黏膜相关淋巴组织（MALT）淋巴瘤。
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