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[在长期给予三嗪净制剂的情况下,其对兔脑兴奋传递的影响]

[Effect of triftazin on the transmission of excitation in the brain of the rabbit under the prolonged administration of the preparation].

作者信息

Nemtsov A V, Rad'ko K A

出版信息

Biull Eksp Biol Med. 1975 Aug;80(8):63-6.

PMID:171014
Abstract

Experiments were conducted on awake rabbits to which trifluoperazine was given daily for 2 weeks in a dose of 1 mg/kg a day; a study was made of the reaction of the cortical neurones in response to the electrostimulation of its adjacent areas. In measuring the dispersions of the poststimular histograms it was found that under the effect of trifluoperazine there occurred a reduction of the value and the duration of the responses of the cortical neurons after the infliction of stimulation. The effect obtained after the administration of trifluoperazine was regarded from the point of view of aggravation of the signal conduction in the neuronal reticula.

摘要

对清醒家兔进行实验,每天给予三氟拉嗪,剂量为1毫克/千克,持续2周;研究皮质神经元对其相邻区域电刺激的反应。在测量刺激后直方图的离散度时发现,在三氟拉嗪的作用下,施加刺激后皮质神经元反应的数值和持续时间均有所降低。从神经元网络中信号传导加重的角度来看待给予三氟拉嗪后获得的效果。

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