Avakian R M, Arushanian E B
Biull Eksp Biol Med. 1975 Aug;80(8):66-9.
In the freely moving rats stimulants of catecholaminergic tramission (DOPA, apomorphine, d,1-amphetamine, and also their combination with disulfiram) reduced the proconvulsive properties of the caudate nucleus. Under the effect of these substances there occurred a shortening of the cortical electroencephalographic response to a single stimulation of the nucleus in the animals given subconvulsive doses of pentaxylenetetrazol and a reduction of the extent of the spike-wave rhythm induced by the repeated caudate stimuli. On the contrary, inhibitors of catecholaminergic transmission (chlorpromazine, haloperidol, alpha-methyltyrosine and disulfiram) intensified the proconvulsive effect of the caudate nucleus.
在自由活动的大鼠中，儿茶酚胺能传递兴奋剂（多巴、阿扑吗啡、d，l-苯丙胺，以及它们与双硫仑的组合）降低了尾状核的惊厥前特性。在这些物质的作用下，给予亚惊厥剂量戊四氮的动物，对尾状核单次刺激的皮质脑电图反应缩短，且重复尾状核刺激诱导的棘波节律范围减小。相反，儿茶酚胺能传递抑制剂（氯丙嗪、氟哌啶醇、α-甲基酪氨酸和双硫仑）增强了尾状核的惊厥前效应。
