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[低剂量氟哌啶醇和氯氮平对猫尾状核电刺激停止后行为变化的影响]

[Effect of low haloperidol and clozapine doses on behavioral shifts in cats occurring after discontinuing electrical stimulation of the caudate nucleus].

作者信息

Arushanian E B, Shishliannikova L V

出版信息

Farmakol Toksikol. 1980 Jul-Aug;43(4):364-8.

PMID:7439368
Abstract

Low doses of haloperidol (0.03-0.06 mg/kg) and clozapine (0.25 mg/kg) facilitate the development of behavioral shifts that arise after discontinuance of repeated low frequency electric stimulation of the caudate nucleus head in cats and potentiate this effect. If is assumed that triggering of tonic inhibitory effects of the nucleus by means of neuroleptics can determine their effect not only on motor activity but also on psychic processes.

摘要

低剂量的氟哌啶醇(0.03 - 0.06毫克/千克)和氯氮平(0.25毫克/千克)有助于在猫尾状核头部重复低频电刺激停止后出现的行为转变的发展,并增强这种效应。据推测,通过抗精神病药物触发该核的强直性抑制作用不仅可以决定它们对运动活动的影响,还可以决定它们对心理过程的影响。

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