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具核梭杆菌FhbB蛋白基因的鉴定，FhbB是一种高度独特的类补体因子H样蛋白1结合蛋白。

Identification of the gene encoding the FhbB protein of Treponema denticola, a highly unique factor H-like protein 1 binding protein.

作者信息

McDowell John V, Frederick Jesse, Stamm Lola, Marconi Richard T

机构信息

Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-0678, USA.

出版信息

Infect Immun. 2007 Feb;75(2):1050-4. doi: 10.1128/IAI.01458-06. Epub 2006 Nov 13.

DOI:10.1128/IAI.01458-06
PMID:17101650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1828522/
Abstract

The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed. The identification of FhbB represents an important step in understanding the contribution of FHL-1 binding in T. denticola pathogenesis and in development of periodontal disease.

摘要

编码具核梭杆菌因子H样蛋白1（FHL-1）结合蛋白FhbB的基因被克隆并进行了特性分析。分析了FhbB的序列保守性、表达情况及特性。FhbB的鉴定是了解FHL-1结合在具核梭杆菌致病机制及牙周疾病发展过程中所起作用的重要一步。

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