Iwashita M, Mimuro T, Watanabe M, Setoyama T, Matsuo A, Adachi T, Takeda Y, Sakamoto S
Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
Horm Res. 1990;33 Suppl 2:21-6. doi: 10.1159/000181561.
Patients with polycystic ovary syndrome (PCOS) had significantly higher levels of total insulin-like growth factor (IGF-I) than those in age- and weight-matched controls (PCOS, 230 +/- 21 ng/ml; control, 180 +/- 16 ng/ml; mean +/- SE, p less than 0.05) as well as free IGF-I (PCOS, 3.8 +/- 0.2 ng/ml; control, 3.0 +/- 0.2 ng/ml; p less than 0.05). These elevated levels of IGF-I were correlated slightly with levels of LH and LH/FSH ratio (r = 0.171, p less than 0.05 and r = 0.239, p less than 0.01, respectively). Elevated fasting levels of insulin and decreased levels of IGF binding protein (32K-BP) were also observed in PCOS, and the levels of 32K-BP in PCOS were negatively correlated with insulin (r = -0.39, p less than 0.01). These results suggest that elevated IGF-I levels and decreased 32K-BP levels in the circulation are one of the endocrinological features of PCOS and that insulin is responsible for the clinical manifestation of decreased 32K-BP levels in PCOS.
多囊卵巢综合征（PCOS）患者的总胰岛素样生长因子（IGF-I）水平显著高于年龄和体重匹配的对照组（PCOS组，230±21 ng/ml；对照组，180±16 ng/ml；均值±标准误，p<0.05），游离IGF-I水平也是如此（PCOS组，3.8±0.2 ng/ml；对照组，3.0±0.2 ng/ml；p<0.05）。这些升高的IGF-I水平与LH水平及LH/FSH比值略有相关（r分别为0.171，p<0.05和r为0.239，p<0.01）。在PCOS患者中还观察到空腹胰岛素水平升高和IGF结合蛋白（32K-BP）水平降低，且PCOS患者的32K-BP水平与胰岛素呈负相关（r=-0.39，p<0.01）。这些结果表明，循环中IGF-I水平升高和32K-BP水平降低是PCOS的内分泌特征之一，并且胰岛素是PCOS患者32K-BP水平降低临床表现的原因。
