Ozbek Zeynep, Cohen Elisabeth J, Hammersmith Kristin M, Rapuano Christopher J
Cornea Service, Wills Eye Hospital, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cornea. 2006 Sep;25(8):890-4. doi: 10.1097/01.ico.0000224649.12214.33.
To compare intraocular pressure (IOP) measurements in patients with keratoconus (KC), pellucid marginal degeneration (PMD), and unilateral penetrating keratoplasty (PK) for KC by Goldmann applanation tonometry (GAT), Tono-Pen tonometry (TP), and Pascal dynamic contour tonometry (DCT).
Patients with KC, PMD, or PK were included in a prospective study. IOPs were measured by GAT, TP, and DCT. Severity of ectasia was determined by the steep curvature by corneal topography and central thinning by contact ultrasound pachymetry. IOP measurements were compared and correlated with disease severity.
Fifty-three eyes of 36 patients were enrolled. Mean age was 45.3 +/- 12.5 years (range: 28-72 years). Twenty-nine eyes had KC, 21 eyes had a PK for KC, and 3 eyes had PMD. Mean DCT, GAT, and TP readings were 16.1 +/- 2.9, 14.3 +/- 4.1, and 13.8 +/- 4.1 mm Hg, respectively. The differences of mean IOP between GAT and DCT and TP and DCT were statistically significant, whereas the difference between GAT and TP was not. Both GAT and TP readings were significantly higher in the PK eyes than the KC and PMD eyes, whereas DCT readings were not. DCT measurements were not significantly different in PK versus non-PK eyes.
DCT is a newly Food and Drug Administration (FDA)-approved device that is designed to measure IOP, independent of corneal thickness, corneal curvature, and ocular rigidity. DCT gave significantly higher IOP readings than GAT and TP in this study. DCT readings were not affected by corneal thickness. DCT may be more accurate in IOP measurement in eyes with KC and PMD.
通过Goldmann压平眼压计(GAT)、Tono-Pen眼压计(TP)和Pascal动态轮廓眼压计(DCT)比较圆锥角膜(KC)、透明边缘变性(PMD)患者以及因KC接受单侧穿透性角膜移植术(PK)患者的眼压测量值。
将KC、PMD或PK患者纳入一项前瞻性研究。通过GAT、TP和DCT测量眼压。通过角膜地形图的陡峭曲率和接触式超声测厚法测量的中央变薄来确定扩张的严重程度。比较眼压测量值并将其与疾病严重程度相关联。
纳入36例患者的53只眼。平均年龄为45.3±12.5岁(范围:28 - 72岁)。29只眼患有KC,21只眼因KC接受了PK,3只眼患有PMD。平均DCT、GAT和TP读数分别为16.1±2.9、14.3±4.1和13.8±4.1 mmHg。GAT与DCT之间以及TP与DCT之间平均眼压的差异具有统计学意义,而GAT与TP之间的差异无统计学意义。PK眼的GAT和TP读数均显著高于KC和PMD眼,而DCT读数则不然。PK眼与非PK眼的DCT测量值无显著差异。
DCT是一种新获得美国食品药品监督管理局(FDA)批准的用于测量眼压的设备,其测量不受角膜厚度、角膜曲率和眼硬度的影响。在本研究中,DCT给出的眼压读数显著高于GAT和TP。DCT读数不受角膜厚度影响。DCT在测量KC和PMD患者的眼压时可能更准确。