Takeuchi K, Niida H, Matsumoto J, Ueshima K, Okabe S
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Jpn J Pharmacol. 1991 Jan;55(1):147-55. doi: 10.1254/jjp.55.147.
We have examined the effect of orally administered capsaicin on gastric motility in the rat to investigate a possible relationship between motility change and cytoprotection induced by this agent. Capsaicin, given orally (1-30 mg/kg), dose-dependently inhibited hemorrhagic band-like lesions induced by ethanol (60% in 150 mM HCl). This protection was significantly mitigated by desensitization of afferent neurons following capsaicin pretreatment 2 weeks before the experiment, and it was also significantly attenuated by prior administration of indomethacin, but not by spantide. Intragastric administration of capsaicin (30 mg/kg) significantly inhibited gastric motility and increased the mucosal blood flow, but had no effect on the transmucosal potential difference of the stomach. These functional changes induced by capsaicin were also less marked in the afferent neuronal desensitized rat, and they were significantly attenuated by indomethacin but not by spantide. These results suggest that the mucosal protection by intragastric capsaicin may be associated with the inhibition of gastric motility and the increase of mucosal blood flow. These responses may be induced by activation of primary afferent neurons which are probably sensitized by endogenous prostaglandins.
我们研究了口服辣椒素对大鼠胃动力的影响，以探讨这种药物引起的动力变化与细胞保护之间的可能关系。口服辣椒素（1-30毫克/千克）剂量依赖性地抑制乙醇（60%溶于150毫摩尔盐酸）诱导的出血带状病变。在实验前2周用辣椒素预处理使传入神经元脱敏后，这种保护作用明显减弱，并且预先给予吲哚美辛也使其明显减弱，但喷替肽没有这种作用。胃内给予辣椒素（30毫克/千克）显著抑制胃动力并增加黏膜血流量，但对胃的跨黏膜电位差没有影响。辣椒素诱导的这些功能变化在传入神经元脱敏的大鼠中也不太明显，并且它们被吲哚美辛显著减弱，但喷替肽没有这种作用。这些结果表明，胃内辣椒素的黏膜保护作用可能与胃动力的抑制和黏膜血流量的增加有关。这些反应可能是由初级传入神经元的激活引起的，而初级传入神经元可能被内源性前列腺素致敏。
