Ageep Ali K, Malik Aml A, Elkarsani Mubarak S
Department of Pathology, Faculty of Medicine, Red Sea University, Portsudan, Sudan.
Saudi Med J. 2006 Nov;27(11):1711-3.
To study the clinical presentations and laboratory findings of patients presented with fever in a Hospital in Portsudan, Sudan and to detect dengue virus antibodies in their blood.
This study was carried in Almwani Hospital during the period from April to July 2005. Eighty-four patients were included in this hospital-based study. All of them had fever. Their blood films, Widal tests for typhoid, stools and urine investigations were normal. The clinical data were collected using questionnaires. Two samples of blood were taken. One was for general hematological investigation (white blood cell and platelets count), while serum was taken from the other sample for serological detection of the dengue virus antibodies using the enzyme-linked immunosorbent assay (ELISA) technique.
The fever was associated with vomiting (22 patients) and abdominal pain (44 patients). In 93% of the cases bleeding (epistaxes, purpura, malena, hematemesis, and others) occurred. Routine laboratory findings were leucopenia (90% of the cases) and thrombocytopenia (88% of the cases). The diagnosis was confirmed by ELISA detection of dengue virus immunoglobulin M antibodies (in 88% of the patient's sera).
In endemic areas with mosquitoes such as Aedes aegypti, infection with dengue virus should highly be suspected in patients presented with fever. The ELISA or rapid tests for detection of the viral antibodies should be added to the routine investigations to any patient with complain of fever with no obvious cause. Surveillance program and mosquito control measures should be activated in Portsudan.
研究苏丹苏丹港一家医院中发热患者的临床表现和实验室检查结果，并检测其血液中的登革热病毒抗体。
本研究于2005年4月至7月在阿尔姆瓦尼医院进行。这项基于医院的研究纳入了84名患者。他们均有发热症状。他们的血涂片、伤寒肥达试验、粪便和尿液检查均正常。临床数据通过问卷调查收集。采集两份血液样本。一份用于一般血液学检查（白细胞和血小板计数），另一份样本采集血清，采用酶联免疫吸附测定（ELISA）技术进行登革热病毒抗体的血清学检测。
发热伴有呕吐（22例患者）和腹痛（44例患者）。93%的病例出现出血（鼻出血、紫癜、黑便、呕血等）。常规实验室检查结果为白细胞减少（90%的病例）和血小板减少（88%的病例）。通过ELISA检测登革热病毒免疫球蛋白M抗体（88%的患者血清中）确诊。
在有埃及伊蚊等蚊子的流行地区，对于出现发热的患者应高度怀疑感染登革热病毒。对于任何主诉发热且无明显病因的患者，应在常规检查中增加ELISA或快速检测病毒抗体的项目。应在苏丹港启动监测计划和蚊虫控制措施。
