Davies Philip L, Doull Iolo J, Child Frances
Department of Respiratory Paediatrics, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK.
Pediatr Pulmonol. 2007 Jan;42(1):23-8. doi: 10.1002/ppul.20523.
The aim of this study was to assess the validity of the interrupter technique (Rint) in measuring airway responsiveness in children with cystic fibrosis. Fifty children (aged 6-16 years) with cystic fibrosis performed six Rint measurements followed by three acceptable forced expiratory maneuvers. Each child then inhaled 5 mg of nebulized salbutamol by facemask. After 20 min the Rint and forced expiratory measurements were repeated. In the population as a whole a moderate but significant correlation between inverse Rint and FEV1 values was observed, both before and after inhaled bronchodilator (r=0.71 and 0.72, respectively, P < 0.001). However, when changes in Rint and FEV1 readings following inhaled bronchodilator were examined, no relationship was seen. Indeed, the two methods identified completely different subsets of children as being bronchodilator responsive. These results indicate that although a relationship exists between Rint and FEV1 in the whole population, this is not the case in individual children. Rint and FEV1 reflect different aspects of lung function. It is not appropriate to use Rint as a simple alternative for FEV1 in children with cystic fibrosis when assessing airway responsiveness.
本研究的目的是评估中断器技术（Rint）在测量囊性纤维化患儿气道反应性方面的有效性。50名年龄在6至16岁之间的囊性纤维化患儿进行了6次Rint测量，随后进行了3次可接受的用力呼气动作。然后，每个患儿通过面罩吸入5毫克雾化沙丁胺醇。20分钟后，重复进行Rint和用力呼气测量。在整个研究人群中，吸入支气管扩张剂前后，Rint倒数与FEV1值之间均观察到中度但显著的相关性（分别为r = 0.71和0.72，P < 0.001）。然而，当检查吸入支气管扩张剂后Rint和FEV1读数的变化时，未发现两者之间存在关联。实际上，这两种方法确定的支气管扩张剂反应性患儿子集完全不同。这些结果表明，虽然在整个人群中Rint与FEV1之间存在关联，但在个体患儿中并非如此。Rint和FEV1反映了肺功能的不同方面。在评估囊性纤维化患儿的气道反应性时，将Rint作为FEV1的简单替代方法是不合适的。
