Beydon Nicole, Amsallem Francis, Bellet Mireille, Boulé Michèle, Chaussain Michèle, Denjean André, Matran Régis, Pin Isabelle, Alberti Corinne, Gaultier Claude
Department of Physiology of the Robert Debré Teaching Hospital, Paris, France.
Am J Respir Crit Care Med. 2002 Oct 15;166(8):1099-104. doi: 10.1164/rccm.200205-421OC.
Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary function in 39 preschool children with CF (height, 90-130 cm; 16 homozygous Delta F508) and in 79 healthy control children. Functional residual capacity (helium dilution technique) and expiratory interrupter resistance (Rint(exp)) (interrupter technique) were measured. As compared with control children, children with CF had significantly higher Rint(exp), expressed as absolute values and as Z-scores (1.05 +/- 0.36 versus 0.80 +/- 0.20 kPa.L(-1). second, p < 0.0001; and 1.31 +/- 1.72 versus 0.19 +/- 0.97, p < 0.0001), and significantly lower specific expiratory interrupter conductance (1.29 +/- 0.34 versus 1.63 +/- 0.43 kPa(-1). second, p < 0.0001). The effect of the bronchodilator salbutamol on Rint(exp) was not significantly different between children with CF and control children. Rint(exp) Z-scores were significantly higher in children with CF who were exposed to passive smoke (n = 8) (p < 0.03). Children with CF and with a history of respiratory symptoms (n = 31) had significantly higher functional residual capacity Z-scores (p < 0.02) and lower specific expiratory interrupter conductance Z-scores (p < 0.04). Genotype did not influence the data. We conclude that Rint(exp) and functional residual capacity measurements may help to follow young children with CF who are unable to perform reproducible forced expiratory maneuvers.
针对患有囊性纤维化（CF）的学龄前儿童，很少有人评估其肺功能测试。这项多中心研究的目的是比较39名患有CF的学龄前儿童（身高90 - 130厘米；16名纯合子Delta F508）与79名健康对照儿童的肺功能。测量了功能残气量（氦稀释技术）和呼气阻断阻力（Rint(exp)）（阻断技术）。与对照儿童相比，CF患儿的Rint(exp)显著更高，以绝对值和Z分数表示（分别为1.05±0.36与0.80±0.20 kPa·L⁻¹·秒，p < 0.0001；以及1.31±1.72与0.19±0.97，p < 0.0001），而比特定呼气阻断传导率显著更低（1.29±0.34与1.63±0.43 kPa⁻¹·秒，p < 0.0001）。支气管扩张剂沙丁胺醇对CF患儿和对照儿童的Rint(exp)的影响没有显著差异。暴露于被动吸烟的CF患儿（n = 8）的Rint(exp) Z分数显著更高（p < 0.03）。有呼吸道症状病史的CF患儿（n = 31）的功能残气量Z分数显著更高（p < 0.02），而比特定呼气阻断传导率Z分数更低（p < 0.04）。基因型不影响这些数据。我们得出结论，Rint(exp)和功能残气量测量可能有助于跟踪无法进行可重复用力呼气动作的CF幼儿。
