Cao Lan, Ratner Buddy D, Horbett Thomas A
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
J Biomed Mater Res A. 2007 Apr;81(1):12-23. doi: 10.1002/jbm.a.30906.
In this study, a glow discharge plasma deposition system previously used for treating flat substrates was successfully modified and optimized to produce a PEO-like coating on the inner surface of 1-3 mm ID polyethylene tubing by deposition of tetra ethylene glycol dimethyl ether (tetraglyme). The plasma treatment conditions were varied in order to find operating values that would produce coatings with the ultralow (< 5 ng/cm(2)) fibrinogen adsorption (Gamma(Fg)) previously shown necessary to significantly reduce platelet adhesion. The flow rate of gaseous tetraglyme monomer, pressure, and plasma generating power were found to be the most important parameters affecting the uniformity and chemical structure of the coating. The coating uniformity and quality were assessed by measuring Gamma(Fg) at positions 1 cm apart along the entire tube and the fraction of C1s carbon that was in an ether bond (ether-carbon ratio) by electron spectroscopy of chemical analysis. Under optimized conditions, tetraglyme plasma-coated tubes of up to 20 cm in length had ultralow Gamma(Fg). The region of the tube that had ultralow Gamma(Fg) also had C1s ether-carbon ratios that are greater than 50%.
在本研究中，对先前用于处理平面基板的辉光放电等离子体沉积系统进行了成功改进和优化，通过沉积四甘醇二甲醚（四甘醇二甲醚）在内径为1 - 3毫米的聚乙烯管内表面制备类等离子体电解氧化（PEO）涂层。改变等离子体处理条件，以找到能产生具有超低（< 5 ng/cm²）纤维蛋白原吸附（Γ(Fg)）涂层的操作值，此前已表明这种吸附对于显著减少血小板粘附是必要的。发现气态四甘醇二甲醚单体的流速、压力和等离子体产生功率是影响涂层均匀性和化学结构的最重要参数。通过沿整个管子每隔1厘米测量Γ(Fg)以及通过化学分析电子能谱测量处于醚键中的C1s碳的比例（醚 - 碳比）来评估涂层的均匀性和质量。在优化条件下，长度达20厘米的四甘醇二甲醚等离子体涂层管具有超低的Γ(Fg)。具有超低Γ(Fg)的管区域的C1s醚 - 碳比也大于50%。
