Ulla M, Thobois S, Lemaire J-J, Schmitt A, Derost P, Broussolle E, Llorca P-M, Durif F
Univ Clermont 1, UFR Médecine, Clermont-Ferrand, France.
J Neurol Neurosurg Psychiatry. 2006 Dec;77(12):1363-6. doi: 10.1136/jnnp.2006.096628.
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.
我们报告了一例帕金森病患者，其接受双侧丘脑底核深部脑刺激治疗后获益，但在主要刺激黑质时出现急性且可重复的躁狂行为。正电子发射断层扫描显示右侧背外侧前额叶和颞下回皮质、左侧前扣带回皮质激活，左侧岛叶失活。这表明与躁狂相关的皮质激活变化是由皮质下驱动的，尤其涉及黑质。
