Ten Tusscher K H W J, Panfilov A V
Department of Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Phys Med Biol. 2006 Dec 7;51(23):6141-56. doi: 10.1088/0031-9155/51/23/014. Epub 2006 Nov 8.
In this paper, we formulate a model for human ventricular cells that is efficient enough for whole organ arrhythmia simulations yet detailed enough to capture the effects of cell level processes such as current blocks and channelopathies. The model is obtained from our detailed human ventricular cell model by using mathematical techniques to reduce the number of variables from 19 to nine. We carefully compare our full and reduced model at the single cell, cable and 2D tissue level and show that the reduced model has a very similar behaviour. Importantly, the new model correctly produces the effects of current blocks and channelopathies on AP and spiral wave behaviour, processes at the core of current day arrhythmia research. The new model is well over four times more efficient than the full model. We conclude that the new model can be used for efficient simulations of the effects of current changes on arrhythmias in the human heart.
在本文中，我们构建了一个人类心室细胞模型，该模型对于全器官心律失常模拟而言效率足够高，同时又足够详细，能够捕捉电流阻断和离子通道病等细胞水平过程的影响。该模型是通过数学技术将我们详细的人类心室细胞模型中的变量数量从19个减少到9个而得到的。我们在单细胞、电缆和二维组织水平上仔细比较了完整模型和简化模型，结果表明简化模型具有非常相似的行为。重要的是，新模型正确地产生了电流阻断和离子通道病对动作电位和螺旋波行为的影响，而这些过程是当今心律失常研究的核心。新模型的效率比完整模型高出四倍多。我们得出结论，新模型可用于高效模拟电流变化对人类心脏心律失常的影响。
