Ruan Wen-jing, Lai Mao-de, Zhou Jian-guang
Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310006, China.
J Zhejiang Univ Sci B. 2006 Dec;7(12):1006-14. doi: 10.1631/jzus.2006.B1006.
Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM). In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of CHM. Experiments showed that CHM played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that CHM could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of CHM in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, CHM could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.
目前,肿瘤学家对从中药中寻找抗癌药物有着浓厚的兴趣。过去,临床数据表明一些草药具有抗癌特性,但西方科学家因缺乏他们所认为的科学证据而怀疑中药的科学有效性。最近,从西方的角度来看,癌症研究领域在中药抗癌作用方面取得了令人鼓舞的成果。实验表明,中药通过诱导细胞凋亡和分化、增强免疫系统、抑制血管生成、逆转多药耐药性等发挥其抗癌作用。临床试验表明,中药可以提高生存率、增加肿瘤反应、改善生活质量或降低化疗毒性,尽管在临床试验背景下,中药对人体的客观作用仍有许多有待确定。有趣的是,实验室实验和临床试验均表明,与化疗联合使用时,中药可以提高疗效水平并降低毒副反应。这些事实提高了草药与化疗联合使用的可行性,尽管该领域仍有许多有待研究之处。