Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Nutrients. 2021 Feb 8;13(2):555. doi: 10.3390/nu13020555.
Tumors are one of the most life-threatening diseases, and a variety of cancer treatment options have been continuously introduced in order to overcome cancer and improve conventional therapy. (), which is a perennial plant belonging to the genus of the Crassulaceae family, has been revealed to exhibit pharmacological properties against various tumors in numerous studies. The present review aimed to discuss the biological actions and underlying molecular mechanisms of and its representative compounds-kaempferol and quercetin-against tumors. reportedly has antiproliferative, anti-angiogenic, and antimetastatic activities against various types of malignant tumors through the induction of apoptosis and cell cycle arrest, a blockade of downstream vascular endothelial growth factor (VEGF)-VEGFR2 pathways, and the regulation of epithelial-to-mesenchymal transition. In addition, emerging studies have highlighted the antitumor efficacy of kaempferol and quercetin. Interestingly, it was found that alterations of the mitogen-activated protein kinase (MAPK) signaling cascades are involved in the pivotal mechanisms of the antitumor effects of and its two compounds against cancer cell overgrowth, angiogenesis, and metastasis. In summary, could be considered a preventive and therapeutic medicinal plant which exhibits antitumor actions by reversing altered patterns of MAPK cascades, and kaempferol and quercetin might be potential components that can contribute to the efficacy and underlying mechanism of .
肿瘤是最具威胁生命的疾病之一，为了攻克癌症、提高常规疗法的疗效，不断引入各种癌症治疗选择。 (), 是景天科伽蓝菜属的多年生植物，大量研究表明其对多种肿瘤具有药理作用。本综述旨在讨论 及其代表性化合物山奈酚和槲皮素对肿瘤的生物学作用和潜在的分子机制。 reportedly 具有抗增殖、抗血管生成和抗转移活性，可通过诱导细胞凋亡和细胞周期阻滞、阻断下游血管内皮生长因子（VEGF）-VEGFR2 通路以及调节上皮间质转化来抑制各种类型的恶性肿瘤。此外，新的研究强调了山奈酚和槲皮素的抗肿瘤功效。有趣的是，研究发现，丝裂原活化蛋白激酶 (MAPK) 信号级联的改变参与了 及其两种化合物抑制肿瘤细胞过度生长、血管生成和转移的抗肿瘤作用的关键机制。综上所述， 可被视为一种具有预防和治疗作用的药用植物，通过逆转 MAPK 级联的改变模式发挥抗肿瘤作用，山奈酚和槲皮素可能是具有增效作用的潜在成分，并有助于阐明 的作用机制。
