Ladinsky Glenn A, Wehrli Felix W
Division of Renal, Electrolytes & Hypertension, University of Pennsylvania, 700 Clinical Research Bldg., 415 Curie Blvd., Philadelphia, PA 19104-4218, USA.
Curr Osteoporos Rep. 2006 Dec;4(4):140-7. doi: 10.1007/s11914-996-0022-5.
In determining fracture risk, it has become apparent that bone mineral density accounts for only a portion of bone strength, with the remainder being determined by the material and structural properties of the bone tissue. Over the past 15 years, high-resolution MRI has provided a window into the structural nature of bone disease. Cross-sectional studies imaging the trabecular bone in patients with conditions ranging from postmenopausal osteoporosis to organ transplantation to renal osteodystrophy have all demonstrated a correlation of microarchitecture with fracture burden and have done so at a variety of anatomic sites. Recently, the utility of longitudinal studies for monitoring treatment in vivo has been demonstrated. This technique is noninvasive, involving no contrast or ionizing radiation, and provides useful clinical information independent of bone mineral density, thereby allowing for better classification of those at high risk for fracture.
在确定骨折风险时，显而易见的是，骨矿物质密度仅占骨强度的一部分，其余部分则由骨组织的材料和结构特性决定。在过去15年中，高分辨率磁共振成像为了解骨疾病的结构本质提供了一个窗口。对从绝经后骨质疏松症到器官移植再到肾性骨营养不良等各种病症患者的小梁骨进行横断面成像研究，均已证明微观结构与骨折负荷之间存在相关性，并且在多个解剖部位都得到了验证。最近，纵向研究在体内监测治疗的效用也得到了证实。该技术是非侵入性的，无需使用造影剂或电离辐射，并且能提供独立于骨矿物质密度的有用临床信息，从而有助于更好地对骨折高危人群进行分类。
