DRD2基因C957T多态性与COMT基因Val158Met多态性在人类工作记忆能力方面存在相互作用。
DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.
作者信息
Xu Haiyan, Kellendonk Christoph B, Simpson Eleanor H, Keilp John G, Bruder Gerard E, Polan H Jonathan, Kandel Eric R, Gilliam T Conrad
机构信息
Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
出版信息
Schizophr Res. 2007 Feb;90(1-3):104-7. doi: 10.1016/j.schres.2006.10.001. Epub 2006 Nov 17.
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory performance in 188 healthy adults. Subjects having the DRD2 C/C allele showed the poorest performance in a word serial position test. Moreover, the effect of the C957T genotype was strengthened when interaction with the COMT Val158Met polymorphism was included in the analysis. We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
多巴胺D2受体（DRD2）基因中的C957T多态性以及儿茶酚-O-甲基转移酶（COMT）基因中的Val158Met多态性会影响多巴胺传递，并且已发现与精神分裂症有关。由于小鼠中的DRD2和人类中的COMT基因调节工作记忆，我们研究了这两种多态性与188名健康成年人工作记忆表现之间的关系及可能的相互作用。具有DRD2 C/C等位基因的受试者在单词序列位置测试中表现最差。此外，当分析中纳入与COMT Val158Met多态性的相互作用时，C95T基因型的影响会增强。我们认为，DRD2 C957T和COMT Val158Met的相互作用可能与精神分裂症中某些工作记忆缺陷的产生有关。
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