Liu Der-Zen, Sinchaikul Supachok, Reddy Peddiahgari Vasu Govardhana, Chang Meng-Yang, Chen Shui-Tein
Graduate Institute of Biomedical Materials, Taipei Medical University, Taipei 110, Taiwan.
Bioorg Med Chem Lett. 2007 Feb 1;17(3):617-20. doi: 10.1016/j.bmcl.2006.11.008. Epub 2006 Nov 7.
A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2'-paclitaxel and methyl 2'-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.
