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本文引用的文献

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Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.基于同源建模和虚拟筛选的人类葡萄糖转运蛋白1抑制剂发现
ACS Chem Biol. 2016 Jul 15;11(7):1908-16. doi: 10.1021/acschembio.6b00304. Epub 2016 May 11.
2
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.细胞松弛素B和苯丙氨酸酰胺对人类葡萄糖转运蛋白GLUT1的抑制机制是保守的。
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4711-6. doi: 10.1073/pnas.1603735113. Epub 2016 Apr 12.
3
Identification of novel GLUT inhibitors.新型葡萄糖转运蛋白抑制剂的鉴定
Bioorg Med Chem Lett. 2016 Apr 1;26(7):1732-7. doi: 10.1016/j.bmcl.2016.02.050. Epub 2016 Feb 19.
4
Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer.靶向瓦伯格效应的半乳糖共轭铂（II）配合物用于治疗非小细胞肺癌和结肠癌。
Eur J Med Chem. 2016 Mar 3;110:32-42. doi: 10.1016/j.ejmech.2016.01.016. Epub 2016 Jan 14.
5
Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency.三庚酸甘油酯可显著减轻葡萄糖转运蛋白1缺乏症患者的阵发性运动障碍。
J Neurol Neurosurg Psychiatry. 2016 May;87(5):550-3. doi: 10.1136/jnnp-2015-311475. Epub 2015 Nov 3.
6
Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells.靶向葡萄糖转运蛋白1的水杨基酮肟类化合物限制肺癌细胞的能量供应。
ChemMedChem. 2015 Nov;10(11):1892-900. doi: 10.1002/cmdc.201500320. Epub 2015 Sep 1.
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Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.姜黄素通过减弱GLUT1/MT1-MMP/MMP2途径抑制肺癌侵袭和转移。
Int J Clin Exp Med. 2015 Jun 15;8(6):8948-57. eCollection 2015.
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Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1.芹菜素通过抑制葡萄糖转运蛋白-1来抑制腺样囊性癌的增殖。
Mol Med Rep. 2015 Nov;12(5):6461-6. doi: 10.3892/mmr.2015.4233. Epub 2015 Aug 20.
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Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo.使用芹菜素抑制GLUT-1表达和PI3K/Akt信号传导可提高喉癌在体内的放射敏感性。
Oncol Rep. 2015 Oct;34(4):1805-14. doi: 10.3892/or.2015.4158. Epub 2015 Jul 28.
10
Xanthohumol impairs glucose uptake by a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) and impacts the process of placentation.黄腐酚会损害人孕早期绒毛外滋养层细胞系（HTR-8/SVneo细胞）的葡萄糖摄取，并影响胎盘形成过程。
Mol Hum Reprod. 2015 Oct;21(10):803-15. doi: 10.1093/molehr/gav043. Epub 2015 Jul 20.

与膜葡萄糖转运蛋白相互作用的抗癌剂。

Anticancer agents interacting with membrane glucose transporters.

作者信息

Granchi C, Fortunato S, Minutolo F

机构信息

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.

出版信息

Medchemcomm. 2016 Sep 1;7(9):1716-1729. doi: 10.1039/C6MD00287K. Epub 2016 Jul 8.

DOI:10.1039/C6MD00287K
PMID:28042452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5198910/
Abstract

The altered metabolism observed in cancer cells generally consists in increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore GLUTs are considered as suitable targets for the treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.

摘要

癌细胞中观察到的代谢改变通常表现为葡萄糖摄取增加和糖酵解活性增强。这与葡萄糖转运蛋白（GLUTs）的过度表达有关，这些蛋白促进葡萄糖跨质膜摄取，并在癌细胞存活中起关键作用。因此，GLUTs被认为是癌症治疗的合适靶点。在此，我们综述了一些最近作为潜在抗癌药物开发的最相关的GLUT抑制剂。