与膜葡萄糖转运蛋白相互作用的抗癌剂。
Anticancer agents interacting with membrane glucose transporters.
作者信息
Granchi C, Fortunato S, Minutolo F
机构信息
Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
出版信息
Medchemcomm. 2016 Sep 1;7(9):1716-1729. doi: 10.1039/C6MD00287K. Epub 2016 Jul 8.
Abstract
The altered metabolism observed in cancer cells generally consists in increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore GLUTs are considered as suitable targets for the treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.
摘要
癌细胞中观察到的代谢改变通常表现为葡萄糖摄取增加和糖酵解活性增强。这与葡萄糖转运蛋白（GLUTs）的过度表达有关，这些蛋白促进葡萄糖跨质膜摄取，并在癌细胞存活中起关键作用。因此，GLUTs被认为是癌症治疗的合适靶点。在此，我们综述了一些最近作为潜在抗癌药物开发的最相关的GLUT抑制剂。
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