Koga Ichiro, Odawara Takashi, Matsuda Masakazu, Sugiura Wataru, Goto Mieko, Nakamura Tetsuya, Iwamoto Aikichi
Division of Infectious diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
Microbes Infect. 2006 Nov-Dec;8(14-15):2872-9. doi: 10.1016/j.micinf.2006.09.003. Epub 2006 Oct 23.
Increasing syphilis incidence among men who have sex with men (MSM) has been reported. The index case was a human immunodeficiency virus type 1 (HIV-1)-positive MSM who presented coincidentally with the secondary syphilis and a rebound of plasma viral load after complete suppression of HIV-1 (below 50 copies/ml) for 13 months with potent antiretroviral therapy (PART), suggesting a possibility of HIV-1 superinfection. We analyzed HIV-1 sequences before and after syphilis in four HIV-1-positive patients including the index case to explore drug resistance mutations (DRMs) and a possibility of HIV-1 superinfection. There were patients who obtained DRMs around syphilis infection but no evidence of HIV-1 superinfection was obtained. Our results underline the importance of strict adherence to PART.
据报道，男男性行为者（MSM）中梅毒发病率不断上升。索引病例是一名1型人类免疫缺陷病毒（HIV-1）阳性的男男性行为者，该患者同时患有二期梅毒，并且在接受强效抗逆转录病毒疗法（PART）使HIV-1被完全抑制（低于50拷贝/毫升）达13个月后出现血浆病毒载量反弹，提示存在HIV-1重复感染的可能性。我们分析了包括索引病例在内的4例HIV-1阳性患者在患梅毒前后的HIV-1序列，以探索耐药性突变（DRM）及HIV-1重复感染的可能性。有患者在梅毒感染前后出现了耐药性突变，但未获得HIV-1重复感染的证据。我们的结果强调了严格坚持PART治疗的重要性。
