DNA修复：黄金岁月中的校正

DNA repair: corrections in the golden years.

作者信息

Gottschling Daniel E

机构信息

Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

出版信息

Curr Biol. 2006 Nov 21;16(22):R956-8. doi: 10.1016/j.cub.2006.10.016.

DOI:10.1016/j.cub.2006.10.016

PMID:17113375

Abstract

Genetic changes increase with the age of organisms, but the basis for this increase is unclear. A study has found that the major pathway of DNA repair is altered with age in the testes of male Drosophila, thus providing a powerful system to dissect the basis for age-related genomic changes.

摘要

基因变化会随着生物体年龄的增长而增加，但其增加的基础尚不清楚。一项研究发现，在雄性果蝇的睾丸中，DNA修复的主要途径会随着年龄的增长而改变，从而为剖析与年龄相关的基因组变化的基础提供了一个有力的系统。