Koltovaia N A
Genetika. 2009 Jan;45(1):5-21.
Molecular mechanisms of activation of DNA repair and checkpoint control by double-strand breaks are considered. They include phosphorylation by protein kinases of repair and checkpoint proteins resulting in their activation, alteration of affinity to other proteins, and alteration of their localization.
本文探讨了双链断裂激活DNA修复和检查点控制的分子机制。这些机制包括修复蛋白和检查点蛋白被蛋白激酶磷酸化,从而导致它们的激活、与其他蛋白亲和力的改变以及定位的改变。