Kendall T J, Featherstone J M, Mead G M, Hayes M C, Theaker J M
Department of Cellular Pathology, Southampton University Hospitals NHS Trust, Tremona Road, SO16 6YD, Southampton, Hampshire, UK.
Int Urol Nephrol. 2006;38(3-4):643-6. doi: 10.1007/s11255-005-4984-5.
Adult testicular dermoid tumours are rare tumours with no reported potential for recurrent or metastatic spread. Despite this they are currently classified as mature teratoma and managed as if they have equivalent malignant potential. This report describes two cases of adult mature teratoma of dermoid type and questions the classification and pathogenesis of this disease. In one of the cases there was a clear history of a testicular lump arising pre-pubertally, raising the possibility that some adult dermoid tumours may in fact be pre-pubertal teratomas that have persisted into adulthood. Classification as a mature teratoma carries with it a follow-up regimen that includes numerous radiological investigations with their attendant radiation exposure. A positive histological diagnosis and separate classification of adult dermoid tumours would allay clinical fears of recurrence and metastasis and negate the need for repeated radiological investigations.
成人睾丸皮样肿瘤是罕见肿瘤，尚无复发性或转移性扩散的报道。尽管如此，它们目前被归类为成熟畸胎瘤，并按具有同等恶性潜能来处理。本报告描述了两例成人皮样型成熟畸胎瘤病例，并对该疾病的分类和发病机制提出质疑。其中一例有明确的青春期前出现睾丸肿块的病史，这增加了一些成人皮样肿瘤实际上可能是持续至成年期的青春期前畸胎瘤的可能性。归类为成熟畸胎瘤会带来一套随访方案，包括多次放射学检查及其伴随的辐射暴露。成人皮样肿瘤的阳性组织学诊断和单独分类将消除临床对复发和转移的担忧，并消除重复进行放射学检查的必要性。
