Trotter J L, Hickey W F, van der Veen R C, Sulze L
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
J Neuroimmunol. 1991 Jul;33(1):55-62. doi: 10.1016/0165-5728(91)90034-5.
Myelin proteolipid protein (PLP) can induce a T cell-mediated chronic relapsing autoimmune encephalomyelitis in animals and therefore is a candidate for an antigen involved in the pathogenesis of multiple sclerosis. In this report, evidence is presented that peripheral blood mononuclear cells from certain multiple sclerosis (MS) patients recognize the intact PLP molecule as well as certain synthetic PLP peptides in proliferation assays. PLP-specific T cell lines could be obtained from six of ten MS patients with early relapsing-remitting disease. These lines recognized more than one PLP peptide and the relevant peptides differed among patients. The relevance of these observations to the pathogenesis of MS remains to be determined.
髓鞘蛋白脂蛋白（PLP）可在动物体内诱导T细胞介导的慢性复发性自身免疫性脑脊髓炎，因此是参与多发性硬化症发病机制的一种抗原候选物。在本报告中，有证据表明，在增殖试验中，某些多发性硬化症（MS）患者的外周血单核细胞能够识别完整的PLP分子以及某些合成的PLP肽。从10例早期复发缓解型MS患者中的6例可获得PLP特异性T细胞系。这些细胞系识别不止一种PLP肽，且不同患者的相关肽有所不同。这些观察结果与MS发病机制的相关性仍有待确定。
