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儿茶素和茶叶提取物对Caco-2细胞叶酸摄取的抑制作用。

Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells.

作者信息

Alemdaroglu N Ceren, Wolffram Siegfried, Boissel Jean-Paul, Closs Ellen, Spahn-Langguth Hildegard, Langguth Peter

机构信息

Institute of Pharmacy, Johannes Gutenberg-University, Mainz, Germany.

出版信息

Planta Med. 2007 Jan;73(1):27-32. doi: 10.1055/s-2006-951745. Epub 2006 Nov 21.

Abstract

In this present study it was aimed to determine whether the catechins contained in green tea and the whole extracts of Camellia sinensis (Theaceae) inhibit the uptake of folic acid by Caco-2 cell monolayers. Our results indicate that (-)-epigallocatechin 3-gallate (EGCG) and (-)-epicatechin 3-gallate (ECG) inhibit cellular folic acid uptake with IC50 values of 34.8 micromol/L and 30.8 micromol/L, respectively. Furthermore, green and black tea extracts were also found to inhibit folic acid uptake with IC50 values of approximately 7.5 and 3.6 mg/mL, respectively. According to these results, simultaneous intake of tea and folic acid may inhibit intestinal folic acid absorption. The consequences with respect to the folate status of the body will need to be examined in vivo.

摘要

在本研究中,旨在确定绿茶中含有的儿茶素以及茶树(山茶科)的全提取物是否会抑制Caco-2细胞单层对叶酸的摄取。我们的结果表明,(-)-表没食子儿茶素3-没食子酸酯(EGCG)和(-)-表儿茶素3-没食子酸酯(ECG)抑制细胞对叶酸的摄取,IC50值分别为34.8微摩尔/升和30.8微摩尔/升。此外,还发现绿茶和红茶提取物抑制叶酸摄取,IC50值分别约为7.5和3.6毫克/毫升。根据这些结果,同时摄入茶和叶酸可能会抑制肠道对叶酸的吸收。关于身体叶酸状态的后果需要在体内进行研究。

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