Nay Bastien, Riache Nassima, Evanno Laurent
Unité Molécules de Communication et Adaptation de Micro-organismes, Muséum National d'Histoire Naturelle-CNRS (FRE 3206), 57 rue Cuvier (CP 54), 75005 Paris, France.
Nat Prod Rep. 2009 Aug;26(8):1044-62. doi: 10.1039/b903905h. Epub 2009 Jun 11.
Natural products containing non-tetramic gamma-hydroxy-gamma-lactams and gamma-alkylidene-gamma-lactams are usually but not exclusively derived from the mixed polyketide-non-ribosomal peptide biosynthetic pathway. Often they are fungal metabolites, although some plant- and marine-derived exceptions exist. Owing to their unique structures and biological properties, they have gained interest in the chemical and biological communities. In this review, we aim to emphasize the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them; 157 references are cited.
含有非四元γ-羟基-γ-内酰胺和γ-亚烷基-γ-内酰胺的天然产物通常（但并非唯一）源自混合聚酮-非核糖体肽生物合成途径。它们通常是真菌代谢产物，不过也存在一些源自植物和海洋的例外情况。由于其独特的结构和生物学特性，它们在化学和生物学领域引起了关注。在本综述中，我们旨在强调这些化合物的结构原创性、生物学特性以及为合成它们所做的努力；引用了157篇参考文献。
