帕金森病与多巴胺转运体神经影像学：一项批判性综述。
Parkinson's disease and dopamine transporter neuroimaging: a critical review.
作者信息
Shih Ming Chi, Hoexter Marcelo Queiroz, Andrade Luiz Augusto Franco de, Bressan Rodrigo Affonseca
机构信息
Laboratório Interdisciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, Rua Dr. Bacelar 334, CEP 04026-001 São Paulo, Brazil.
出版信息
Sao Paulo Med J. 2006 May 4;124(3):168-75. doi: 10.1590/s1516-31802006000300014.
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity).
摘要
帕金森病（PD）是一种常见的神经退行性疾病，主要由黑质中多巴胺能神经元的丧失引起。已经开发了几种核医学放射性示踪剂，用于在帕金森病患者体内评估PD的诊断和疾病进展。用于多巴胺转运体（DAT）的正电子发射断层扫描（PET）和单光子计算机发射断层扫描（SPECT）放射性示踪剂为PD中受影响的突触前多巴胺能系统的完整性提供了良好的标志物。在过去十年中，适用于DAT成像的放射性示踪剂一直是大多数研究工作的主题。在这篇综述中，我们对DAT成像在帕金森病诊断中的效用（敏感性和特异性）进行了批判性讨论。
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