[帕金森病中多巴胺转运体的神经影像学：巴西首次使用[99mTc]-TRODAT-1和单光子发射计算机断层扫描的研究]
[Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil].
作者信息
Shih Ming Chi, Amaro Edson, Ferraz Henrique Ballalai, Hoexter Marcelo Queiroz, Goulart Fabricio Oliveira, Wagner Jairo, Lin Li Fu, Fu Ying Kai, Mari Jair Jesus, de Lacerda Acioly Luiz Tavares, Tufik Sergio, Bressan Rodrigo Affonseca
机构信息
Laboratório Interdiciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, and Departamento de Imagem, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
出版信息
Arq Neuropsiquiatr. 2006 Sep;64(3A):628-34. doi: 10.1590/s0004-282x2006000400021.
BACKGROUND
Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in Parkinsons disease (PD).
OBJECTIVE
To evaluate DAT density in vivo using [99mTc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD.
METHOD
Fifteen PD patients and 15 matched healthy controls scanned with [99mTc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales.
RESULTS
PD patients had significantly lower striatal DAT-BP (mean+/-SD) (0.38+/-0.12) compared to controls (BP=0.84+/-0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho=-0.7, p<0.001) and motor scales (rho=-0.80, p<0.001) were found.
CONCLUSION
[99mTc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.
背景
多巴胺转运体（DAT）神经影像示踪剂被开发用于在帕金森病（PD）患者体内估计多巴胺神经元的损失情况。
目的
使用[99mTc]-TRODAT-1和单光子计算机断层扫描（SPECT）评估巴西PD患者群体体内的DAT密度。
方法
15例PD患者和15例匹配的健康对照者接受了[99mTc]-TRODAT-1（台湾核能研究所）和SPECT扫描。使用结合潜能（BP）计算纹状体DAT密度估计值。患者接受PD量表评估。
结果
与对照组相比，PD患者的纹状体DAT-BP（均值±标准差）显著降低（0.38±0.12），对照组为BP=0.84±0.16；p<0.01。区分PD病例和对照的敏感度和特异度均为100%。发现纹状体DAT-BP与PD严重程度（rho=-0.7，p<0.001）和运动量表（rho=-0.80，p<0.001）之间呈负相关。
结论
[99mTc]TRODAT-1 SPECT扫描能够区分PD患者和对照。该技术是测量DAT密度的有力工具，可用于巴西的临床和研究环境。
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