Althoff C E, Hermann K G, Braun J, Sieper J
Institut für Radiologie, Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Schumannstrasse 20/21, 10117, Berlin, Deutschland.
Z Rheumatol. 2006 Dec;65(8):688-99. doi: 10.1007/s00393-006-0122-8.
Conventional radiography and magnetic resonance imaging (MRI) are currently the most widely used imaging methods for the initial diagnostic evaluation and follow-up of patients with ankylosing spondylitis (AS). Scintigraphy, computed tomography (CT), and positron emission tomography (PET) only play minor roles, although some are being further developed. AS is characterized by inflammatory changes to the sacroiliac joints (SIJs) and spine, as well as asymmetrical arthritis of the peripheral joints and joints near the trunk. The diagnosis of AS is based on clinical parameters and the presence of chronic inflammatory changes to the SIJs on conventional radiographs. Typical radiographic changes also involve the spine. MRI depicts not only chronic changes, but also active inflammatory lesions, which are important for the diagnosis of early disease and precursors of AS. The scoring system of choice for quantifying spinal changes depicted by conventional radiography is the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). MRI allows the quantitative evaluation of changes involving the SIJs and the spine. Various MRI scoring systems have been proposed to quantify these changes, but they require further validation. This review article presents the imaging modalities used in AS patients, typical findings, and relevant methods of analysis. The most recent developments are discussed.
传统放射学检查和磁共振成像(MRI)是目前用于强直性脊柱炎(AS)患者初始诊断评估及随访的最常用成像方法。闪烁扫描、计算机断层扫描(CT)和正电子发射断层扫描(PET)仅起次要作用,尽管其中一些技术仍在进一步发展。AS的特征是骶髂关节(SIJ)和脊柱出现炎症性改变,以及外周关节和躯干附近关节的不对称性关节炎。AS的诊断基于临床参数以及传统X线片上SIJ存在慢性炎症性改变。典型的影像学改变也累及脊柱。MRI不仅能显示慢性改变,还能显示活动性炎性病变,这对早期疾病及AS前驱病变的诊断很重要。用于量化传统放射学检查所显示脊柱改变的首选评分系统是改良斯托克强直性脊柱炎脊柱评分(mSASSS)。MRI可对涉及SIJ和脊柱的改变进行定量评估。已提出多种MRI评分系统来量化这些改变,但它们尚需进一步验证。本文综述介绍了AS患者使用的成像方式、典型表现及相关分析方法,并讨论了最新进展。