López-Schier Hernán, Hudspeth A J
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18615-20. doi: 10.1073/pnas.0608536103. Epub 2006 Nov 21.
The restoration of planar cell polarity is an essential but poorly understood step toward physiological recovery during sensory-organ regeneration. Investigating this issue in the lateral line of the zebrafish, we found that hair cells regenerate in pairs along a single axis established by the restricted localization and oriented division of their progenitors. By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that the uniaxial production of hair cells and the subsequent orientation of their hair bundles are controlled by distinct pathways, whose combination underlies the establishment of hair-cell orientation during development and regeneration. This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia.
平面细胞极性的恢复是感觉器官再生过程中生理恢复的一个重要但了解甚少的步骤。在斑马鱼的侧线中研究这个问题时，我们发现毛细胞沿着由其祖细胞的受限定位和定向分裂所建立的单一轴成对再生。通过分析缺乏平面极性决定因子Vangl2的突变体，我们确定毛细胞的单轴产生及其随后毛束的定向由不同的途径控制，这些途径的组合是发育和再生过程中毛细胞定向建立的基础。这种机制可能代表了一种普遍原则，用于调控重塑上皮中平面细胞极性的长期维持。
